InVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed and manufactured by AdipoGen Life Sciences.
AdipoGen Life Sciences' anti-Asc, pAb (AL177) is the Standard antibody to detect Asc by Western blotting. It can also be used to measure inflammasome activation in vivo, detecting Asc speck formation by Immunofluorescence and by Flow Cytometry.
See our Website for Protocols and Instructions for Flow Cytometry and Immunofluorescence applications using AL177.
InVivoKines™, developed and manufactured by AdipoGen Life Sciences is a new generation of recombinant fusion proteins containing a KIH-Fc domain. InVivoKines™ have high activity and long half-life for immunotherapeutic, preclinical and translational in vivo research.
We have developed a new recombinant mouse IL-1Ra protein with a silent mutated Fc, Fc (LALA-PG)-KIH (human):IL-1Ra (mouse) (monomeric) (rec.), which binds to the receptor IL-1R1 and inhibits binding of IL-1β to its receptor.
This is a unique and important new InVivoKine™ to advance the Inflammasomes Research Field.
AdipoGen Life Sciences offers a panel of unique KO-validated monoclonal antibodies to detect the cleaved p10 and p20 caspase-1 fragments.
anti-Caspase-1 (p20) (mouse), mAb (Casper-1) is the Standard antibody to detect the full-length and cleaved mouse p20 caspase-1 fragment, while anti-Caspase-1 (p10) (mouse), mAb (Casper-2) can be used to detect the full-length and cleaved mouse p10 caspase-1 fragment.
In addition, we offer anti-Caspase-1 (p20) (human), mAb (Bally-1) for studies in human samples.
nhibiting inflammasome activation or targeting inflammasome components are effective in reducing inflammation in animal models.
AdipoGen Life Sciences offers a broad panel of chemical inflammasome modulators, including the Standard inflammasome inhibitors MCC950 or Dapansutrile, the widely used Standard activators Nigericin and Monosodium urate, and the priming reagents PMA and LPS.