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anti-Acetyl-CoA Carboxylase (human), Rabbit Monoclonal (RM232)

Description
Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). The function of ACC is to regulate the metabolism of fatty acids. When the enzyme is active, the product, malonyl-CoA, is produced which is a building block for new fatty acids and can inhibit the transfer of the fatty acyl group from acyl CoA to carnitine with carnitine acyltransferase, which inhibits the beta-oxidation of fatty acids in the mitochondria. There are two ACC forms, alpha (ACC1) and beta (ACC2), encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA.

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Product Details
Synonyms ACC1; Acetyl-Coenzyme A Carboxylase alpha
Product Type Recombinant Antibody
Properties
Clone RM232
Isotype Rabbit IgG
Source/Host Rabbit
Immunogen/Antigen A peptide corresponding to human Acetyl CoA Carboxylase 1.
Application

Immunohistochemistry (IHC): 1:300-1:500 dilution
Western Blot (WB): 1:1000-1:2000 dilution
Crossreactivity Human
Specificity

This antibody reacts to human Acetyl CoA Carboxylase 1. This antibody may also react to mouse or rat Acetyl CoA Carboxylase 1, as predicted by immunogen homology.
Purity Protein A purified.
Purity Detail Protein A affinity purified from an animal origin-free culture supernatant.
Concentration N/A
Formulation Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
Isotype Negative Control

Rabbit IgG

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.
Accession Number Q13085
Declaration Manufactured by RevMab Biosciences.
Shipping and Handling
Shipping BLUE ICE
Long Term Storage -20°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.

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